The Influence of Paracetamol on the Penetration of Sorafenib and Sorafenib N-Oxide Through the Blood–Brain Barrier in Rats

BACKGROUND AND OBJECTIVE: Sorafenib is an oral, multikinase inhibitor with established single-agent activity in several tumor types. Sorafenib was moderately transported by P-glycoprotein (P-gp) and more efficiently by breast cancer resistance protein. The constitutive androstane receptor (CAR) is a...

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Detalles Bibliográficos
Autores principales: Karbownik, Agnieszka, Stanisławiak-Rudowicz, Joanna, Stachowiak, Anna, Romański, Michał, Grześkowiak, Edmund, Szałek, Edyta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677279/
https://www.ncbi.nlm.nih.gov/pubmed/32776310
http://dx.doi.org/10.1007/s13318-020-00639-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677279/
https://www.ncbi.nlm.nih.gov/pubmed/32776310
http://dx.doi.org/10.1007/s13318-020-00639-z

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