Cargando…

The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia

Ferroptosis is an iron-dependent cell death caused by impaired glutathione metabolism, lipid peroxidation and mitochondrial failure. Emerging evidences report a role for ferroptosis in Friedreich's Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of the mitochondria...

Descripción completa

Detalles Bibliográficos
Autores principales:	La Rosa, Piergiorgio, Petrillo, Sara, Turchi, Riccardo, Berardinelli, Francesco, Schirinzi, Tommaso, Vasco, Gessica, Lettieri-Barbato, Daniele, Fiorenza, Maria Teresa, Bertini, Enrico S., Aquilano, Katia, Piemonte, Fiorella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677700/ https://www.ncbi.nlm.nih.gov/pubmed/33197769 http://dx.doi.org/10.1016/j.redox.2020.101791

Ejemplares similares

Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich’s Ataxia Neural Stem Cells
por: La Rosa, Piergiorgio, et al.
Publicado: (2019)

An Overview of the Ferroptosis Hallmarks in Friedreich’s Ataxia
por: Turchi, Riccardo, et al.
Publicado: (2020)

Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich’s Ataxia
por: Petrillo, Sara, et al.
Publicado: (2017)

Ferroptosis in Friedreich’s Ataxia: A Metal-Induced Neurodegenerative Disease
por: La Rosa, Piergiorgio, et al.
Publicado: (2020)

Targeting NRF2 for the Treatment of Friedreich’s Ataxia: A Comparison among Drugs
por: Petrillo, Sara, et al.
Publicado: (2019)

The NRF2 Signaling Network Defines Clinical Biomarkers and Therapeutic Opportunity in Friedreich’s Ataxia
por: La Rosa, Piergiorgio, et al.
Publicado: (2020)

Friedreich ataxia in COVID-19 time: current impact and future possibilities
por: Schirinzi, Tommaso, et al.
Publicado: (2021)

Butyrate prevents visceral adipose tissue inflammation and metabolic alterations in a Friedreich’s ataxia mouse model
por: Turchi, Riccardo, et al.
Publicado: (2023)

Nuclear Factor Erythroid 2-Related Factor 2 Activation Might Mitigate Clinical Symptoms in Friedreich’s Ataxia: Clues of an “Out-Brain Origin” of the Disease From a Family Study
por: Petrillo, Sara, et al.
Publicado: (2021)

Functional and Gait Assessment in Children and Adolescents Affected by Friedreich’s Ataxia: A One-Year Longitudinal Study
por: Vasco, Gessica, et al.
Publicado: (2016)

Robotic and clinical evaluation of upper limb motor performance in patients with Friedreich’s Ataxia: an observational study
por: Germanotta, Marco, et al.
Publicado: (2015)

Friedreich’s Ataxia: A Neuronal Point of View on the Oxidative Stress Hypothesis
por: Carletti, Barbara, et al.
Publicado: (2014)

Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement
por: La Rosa, Piergiorgio, et al.
Publicado: (2020)

Upper Body Physical Rehabilitation for Children with Ataxia through IMU-Based Exergame
por: Romano, Alberto, et al.
Publicado: (2022)

Non-invasive Focal Mechanical Vibrations Delivered by Wearable Devices: An Open-Label Pilot Study in Childhood Ataxia
por: Schirinzi, Tommaso, et al.
Publicado: (2018)

Apparent Opportunities and Hidden Pitfalls: The Conflicting Results of Restoring NRF2-Regulated Redox Metabolism in Friedreich’s Ataxia Pre-Clinical Models and Clinical Trials
por: Tiberi, Jessica, et al.
Publicado: (2023)

One-year outcome of coenzyme Q10 supplementation in ADCK3 ataxia (ARCA2)
por: Schirinzi, Tommaso, et al.
Publicado: (2019)

Friedreich's Ataxia
por: Anderson, J. Wallace
Publicado: (1893)

Antioxidant Response in Human X-Linked Adrenoleukodystrophy Fibroblasts
por: Petrillo, Sara, et al.
Publicado: (2022)

The role of oxidative stress in Friedreich's ataxia
por: Lupoli, Federica, et al.
Publicado: (2017)

The Pathology of Friedreich's Ataxia
por: Rainy, Harry
Publicado: (1905)

Neuroinflammation in Friedreich’s Ataxia
por: Apolloni, Savina, et al.
Publicado: (2022)

The time dimension of neurodegeneration: the example of Friedreich’s ataxia
por: Vannocci, Tommaso, et al.
Publicado: (2017)

Fasting Drives Nrf2-Related Antioxidant Response in Skeletal Muscle
por: Lettieri-Barbato, Daniele, et al.
Publicado: (2020)

Pushing the Limits of Cancer Therapy: The Nutrient Game
por: Lettieri-Barbato, Daniele, et al.
Publicado: (2018)

Effectiveness of rehabilitation intervention in persons with Friedreich ataxia
por: Paparella, Gabriella, et al.
Publicado: (2023)

Is Friedreich ataxia an epigenetic disorder?
por: Kumari, Daman, et al.
Publicado: (2012)

The Pathogenesis of Cardiomyopathy in Friedreich Ataxia
por: Koeppen, Arnulf H., et al.
Publicado: (2015)

Depressive symptoms in Friedreich ataxia
por: Nieto, Antonieta, et al.
Publicado: (2018)

Heart disease in Friedreich’s ataxia
por: Hanson, Emily, et al.
Publicado: (2019)

Drug Repositioning in Friedreich Ataxia
por: Rufini, Alessandra, et al.
Publicado: (2022)

Two Cases of Friedreich’s Ataxia
por: Stephenson, F. H.
Publicado: (1897)

Respiratory Function in Friedreich’s Ataxia
por: Vinante, Elena, et al.
Publicado: (2022)

Impaired Nuclear Nrf2 Translocation Undermines the Oxidative Stress Response in Friedreich Ataxia
por: Paupe, Vincent, et al.
Publicado: (2009)

Cognitive and functional connectivity alterations in Friedreich's ataxia
por: Cocozza, Sirio, et al.
Publicado: (2018)

Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human
por: Lettieri-Barbato, Daniele, et al.
Publicado: (2016)

Friedreich ataxia in a family from Mali, West Africa/Friedreich ataxia in a Malian family
por: Cissé, Cheick A. K., et al.
Publicado: (2021)

Imbalance of Systemic Redox Biomarkers in Children with Epilepsy: Role of Ferroptosis
por: Petrillo, Sara, et al.
Publicado: (2021)

Novel Nrf2-Inducer Prevents Mitochondrial Defects and Oxidative Stress in Friedreich’s Ataxia Models
por: Abeti, Rosella, et al.
Publicado: (2018)

Anaesthesia for a patient with Friedreich's ataxia
por: Ganesan, Ilango
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_rgsju8csmn2k9ahkvutglp9mm0