In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

[Image: see text] Herein we report in vitro metabolic stability in human liver microsomes (HLMs), interactions with cytochrome P450 isoenzymes (CYP3A4, CYP2D6, and CYP2C9), and cytotoxicity analyses on HEK-293, HepG2, Huh7, and WTIIB cell lines of our most recent multitarget directed ligands PF9601N...

Descripción completa

Detalles Bibliográficos
Autores principales: Więckowska, Anna, Szałaj, Natalia, Góral, Izabella, Bucki, Adam, Latacz, Gniewomir, Kiec-Kononowicz, Katarzyna, Bautista-Aguilera, Òscar. M., Romero, Alejandro, Ramos, Eva, Egea, Javier, Farré Alíns, Victor, González-Rodríguez, Águeda, López-Muñoz, Francisco, Chioua, Mourad, Marco-Contelles, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677930/
https://www.ncbi.nlm.nih.gov/pubmed/33143412
http://dx.doi.org/10.1021/acschemneuro.0c00489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7677930/
https://www.ncbi.nlm.nih.gov/pubmed/33143412
http://dx.doi.org/10.1021/acschemneuro.0c00489

Ejemplares similares