Development of a 3D functional assay and identification of biomarkers, predictive for response of high-grade serous ovarian cancer (HGSOC) patients to poly-ADP ribose polymerase inhibitors (PARPis): targeted therapy

BACKGROUND: Poly(ADP-ribose) polymerase inhibitors (PARPis) specifically target homologous recombination deficiency (HRD) cells and display good therapeutic effect in women with advanced-stage BRCA1/2-mutated breast and epithelial ovarian cancer (EOC). However, about 50% of high grade serous ovarian...

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Detalles Bibliográficos
Autores principales: Sheta, Razan, Bachvarova, Magdalena, Plante, Marie, Renaud, Marie-Claude, Sebastianelli, Alexandra, Gregoire, Jean, Navarro, Jamilet Miranda, Perez, Ricardo Bringas, Masson, Jean-Yves, Bachvarov, Dimcho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678187/
https://www.ncbi.nlm.nih.gov/pubmed/33213473
http://dx.doi.org/10.1186/s12967-020-02613-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678187/
https://www.ncbi.nlm.nih.gov/pubmed/33213473
http://dx.doi.org/10.1186/s12967-020-02613-4

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