Human Lung Macrophages Challenged to Oxidants ex vivo: Lysosomal Membrane Sensitization is Associated with Inflammation and Chronic Airflow Limitation

BACKGROUND: The lung macrophage (LM) is involved in most inflammatory processes of the human lung by clearance of dying cells and by wound repair. Upon cellular stress by oxidant challenge in vivo lysosomes may rupture in LMs and leakage of cellular content and cell debris may trigger airway inflamm...

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Detalles Bibliográficos
Autores principales: Persson, Hans Lennart, Sioutas, Apostolos, Jacobson, Petra, Vainikka, Linda K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678820/
https://www.ncbi.nlm.nih.gov/pubmed/33235481
http://dx.doi.org/10.2147/JIR.S280419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7678820/
https://www.ncbi.nlm.nih.gov/pubmed/33235481
http://dx.doi.org/10.2147/JIR.S280419

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