MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection

COVID-19 affects vulnerable populations including elderly individuals and patients with cancer. Natural Killer (NK) cells and innate-immune TRAIL suppress transformed and virally-infected cells. ACE2, and TMPRSS2 protease promote SARS-CoV-2 infectivity, while inflammatory cytokines IL-6, or G-CSF wo...

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Detalles Bibliográficos
Autores principales: Zhou, Lanlan, Huntington, Kelsey, Zhang, Shengliang, Carlsen, Lindsey, So, Eui-Young, Parker, Cassandra, Sahin, Ilyas, Safran, Howard, Kamle, Suchitra, Lee, Chang-Min, Geun Lee, Chun, A. Elias, Jack, S. Campbell, Kerry, T. Naik, Mandar, J. Atwood, Walter, Youssef, Emile, A. Pachter, Jonathan, Navaraj, Arunasalam, A. Seyhan, Attila, Liang, Olin, El-Deiry, Wafik S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679035/
https://www.ncbi.nlm.nih.gov/pubmed/33245731
http://dx.doi.org/10.18632/oncotarget.27799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679035/
https://www.ncbi.nlm.nih.gov/pubmed/33245731
http://dx.doi.org/10.18632/oncotarget.27799

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