Cargando…

Potency and timing of antiviral therapy as determinants of duration of SARS-CoV-2 shedding and intensity of inflammatory response

To affect the COVID-19 pandemic, lifesaving antiviral therapies must be identified. The number of clinical trials that can be performed is limited. We developed mathematical models to project multiple therapeutic approaches. Our models recapitulate off-treatment viral dynamics and predict a three-ph...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goyal, Ashish, Cardozo-Ojeda, E. Fabian, Schiffer, Joshua T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679107/ https://www.ncbi.nlm.nih.gov/pubmed/33097472 http://dx.doi.org/10.1126/sciadv.abc7112

Ejemplares similares

Modeling explains prolonged SARS-CoV-2 nasal shedding relative to lung shedding in remdesivir-treated rhesus macaques
por: Goyal, Ashish, et al.
Publicado: (2022)

Viral load and contact heterogeneity predict SARS-CoV-2 transmission and super-spreading events
por: Goyal, Ashish, et al.
Publicado: (2021)

Wrong person, place and time: viral load and contact network structure predict SARS-CoV-2 transmission and super-spreading events
por: Goyal, Ashish, et al.
Publicado: (2020)

Estimation of the in vivo neutralization potency of eCD4Ig and conditions for AAV-mediated production for SHIV long-term remission
por: Goyal, Ashish, et al.
Publicado: (2022)

Slight reduction in SARS-CoV-2 exposure viral load due to masking results in a significant reduction in transmission with widespread implementation
por: Goyal, Ashish, et al.
Publicado: (2021)

Endogenously Produced SARS-CoV-2 Specific IgG Antibodies May Have a Limited Impact on Clearing Nasal Shedding of Virus during Primary Infection in Humans
por: Yang, Shuyi, et al.
Publicado: (2021)

Incomplete antiviral treatment may induce longer durations of viral shedding during SARS-CoV-2 infection
por: Kim, Kwang Su, et al.
Publicado: (2021)

Mathematical Modeling of Vaccines That Prevent SARS-CoV-2 Transmission
por: Swan, David A., et al.
Publicado: (2021)

Prolonged Duration of Viral Shedding of SARS-CoV-2: A Case Report
por: Fong, Brandon, et al.
Publicado: (2020)

Duration of SARS-CoV-2 shedding: A population-based, Canadian study
por: Phillips, Susan P., et al.
Publicado: (2021)

Duration of viable virus shedding in SARS-CoV-2 omicron variant infection
por: Boucau, Julie, et al.
Publicado: (2022)

SARS‐CoV‐2 infection‐induced immunity and the duration of viral shedding: Results from a Nicaraguan household cohort study
por: Maier, Hannah E., et al.
Publicado: (2022)

Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant–Infected Vaccinees
por: Takahashi, Kenichiro, et al.
Publicado: (2022)

Duration of Shedding of Culturable Virus in SARS-CoV-2 Omicron (BA.1) Infection
por: Boucau, Julie, et al.
Publicado: (2022)

Duration of infectious shedding of SARS-CoV-2 Omicron variant and its relation with symptoms
por: Keske, Şiran, et al.
Publicado: (2023)

Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches
por: Raj, Vinit, et al.
Publicado: (2021)

Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency
por: Zhang, Chun-Hui, et al.
Publicado: (2021)

Duration of viral shedding and culture positivity with postvaccination SARS-CoV-2 delta variant infections
por: Siedner, Mark J., et al.
Publicado: (2022)

Clinical Features and Duration of Viral Shedding in Individuals With SARS-CoV-2 Omicron Variant Infection
por: Jang, Young R, et al.
Publicado: (2022)

Obesity Increases the Duration of Influenza A Virus Shedding in Adults
por: Maier, Hannah E, et al.
Publicado: (2018)

Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses
por: Owens, Katherine, et al.
Publicado: (2023)

Lopinavir/ritonavir did not shorten the duration of SARS CoV-2 shedding in patients with mild pneumonia in Taiwan
por: Cheng, Chien-Yu, et al.
Publicado: (2020)

Short Sleep Duration is Associated with Prolonged Virus Shedding in SARS-CoV-2 Omicron-Infected Patients
por: Lin, Ying Ni, et al.
Publicado: (2023)

480. Duration of Infectious Virus Shedding by SARS-CoV-2 Omicron Variant among Immunocompromised Patients
por: KAMEGAI, K O H E I, et al.
Publicado: (2023)

Analysis of the effect of cytomegalovirus infection in clinical outcomes and prolonged duration of SARS-CoV-2 shedding in intensive care unit patients with COVID-19 pneumonia
por: Shen, Hsiao-Chin, et al.
Publicado: (2023)

Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2
por: Ferrari Gianlupi, Juliano, et al.
Publicado: (2022)

Mathematical Modeling of Within-Host, Untreated, Cytomegalovirus Infection Dynamics after Allogeneic Transplantation
por: Duke, Elizabeth R., et al.
Publicado: (2021)

Enhancing the Antiviral Potency of Nucleobases for Potential Broad-Spectrum Antiviral Therapies
por: Soto-Acosta, Ruben, et al.
Publicado: (2021)

Factors affecting duration of SARS-Cov-2 viral shedding in mildly symptomatic patients isolated in a community facility
por: Cheng, Hui Mei, et al.
Publicado: (2021)

Duration of SARS-CoV-2 shedding and infectivity in the working age population: a systematic review and meta-analysis
por: Rahmani, Alborz, et al.
Publicado: (2022)

An open, retrospective study on the duration of virus shedding for Shanghai patients infected with SARS‐CoV‐2 omicron variants
por: Zou, Hai, et al.
Publicado: (2023)

TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds
por: Haga, Shiori, et al.
Publicado: (2010)

SARS-CoV-2 shedding and infectivity
por: Atkinson, Barry, et al.
Publicado: (2020)

SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis
por: Cevik, Muge, et al.
Publicado: (2021)

Duration of SARS-CoV-2 viral shedding in faeces as a parameter for wastewater-based epidemiology: Re-analysis of patient data using a shedding dynamics model
por: Miura, Fuminari, et al.
Publicado: (2021)

Longitudinal sampling sheds light on SARS-CoV-2 fecal shedding dynamics
por: Coryell, Michael P., et al.
Publicado: (2022)

Duration of viral shedding in patients with COVID-19 and the redetectable positive cases with SARS-CoV-2: A hospital experience
por: Al Qahtani, A A., et al.
Publicado: (2022)

Association between immunity and viral shedding duration in non-severe SARS-CoV-2 Omicron variant-infected patients
por: He, Shaojun, et al.
Publicado: (2022)

2632. Duration of viable SARS-CoV-2 shedding in immunocompromised COVID-19 patients during the widespread vaccination era
por: Kanai, Osamu, et al.
Publicado: (2023)

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies
por: Muecksch, Frauke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ptvp2va3r7781v3ce5t7tt9btv