Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling

BACKGROUND: The therapeutic utility of the effective chemotherapeutic agent cisplatin is hampered by its nephrotoxic effect. We aimed from the current study to examine the possible protective effects of amlodipine through gamma-glutamyl transpeptidase (GGT) enzyme inhibition against cisplatin nephro...

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Detalles Bibliográficos
Autores principales: Azouz, Amany A., Abdel-Nassir Abdel-Razek, Esraa, Abo-Youssef, Amira M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679434/
https://www.ncbi.nlm.nih.gov/pubmed/33250641
http://dx.doi.org/10.1016/j.jsps.2020.08.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679434/
https://www.ncbi.nlm.nih.gov/pubmed/33250641
http://dx.doi.org/10.1016/j.jsps.2020.08.022

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