Cargando…

The KINGS Ins2(+/G32S) Mouse: A Novel Model of β-Cell Endoplasmic Reticulum Stress and Human Diabetes

Animal models are important tools in diabetes research because ethical and logistical constraints limit access to human tissue. β-Cell dysfunction is a common contributor to the pathogenesis of most types of diabetes. Spontaneous hyperglycemia was developed in a colony of C57BL/6J mice at King’s Col...

Descripción completa

Detalles Bibliográficos
Autores principales:	Austin, Amazon L.F., Daniels Gatward, Lydia F., Cnop, Miriam, Santos, Gabriel, Andersson, David, Sharp, Sally, Gentry, Clive, Bevan, Stuart, Jones, Peter M., King, Aileen J.F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2020
Materias:	Islet Studies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679781/ https://www.ncbi.nlm.nih.gov/pubmed/32994272 http://dx.doi.org/10.2337/db20-0570

Ejemplares similares

Beta cell endoplasmic reticulum stress drives diabetes in the KINGS mouse without causing mass beta cell loss
por: Daniels Gatward, Lydia F., et al.
Publicado: (2022)

Cytokine-Induced β-Cell Death Is Independent of Endoplasmic Reticulum Stress Signaling
por: Åkerfeldt, Mia C., et al.
Publicado: (2008)

Endoplasmic Reticulum Chaperone Glucose-Regulated Protein 94 Is Essential for Proinsulin Handling
por: Ghiasi, Seyed Mojtaba, et al.
Publicado: (2019)

Islet β-Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model
por: Tersey, Sarah A., et al.
Publicado: (2012)

Roles of IP(3)R and RyR Ca(2+) Channels in Endoplasmic Reticulum Stress and β-Cell Death
por: Luciani, Dan S., et al.
Publicado: (2009)

Mechanisms of Control of the Free Ca(2+) Concentration in the Endoplasmic Reticulum of Mouse Pancreatic β-Cells: Interplay With Cell Metabolism and [Ca(2+)](c) and Role of SERCA2b and SERCA3
por: Ravier, Magalie A., et al.
Publicado: (2011)

Combination Therapy With Glucagon-Like Peptide-1 and Gastrin Restores Normoglycemia in Diabetic NOD Mice
por: Suarez-Pinzon, Wilma L., et al.
Publicado: (2008)

Somatostatin Secreted by Islet δ-Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function
por: Hauge-Evans, Astrid C., et al.
Publicado: (2009)

Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection
por: Schulte, Barbara M., et al.
Publicado: (2012)

Progressive Erosion of β-Cell Function Precedes the Onset of Hyperglycemia in the NOD Mouse Model of Type 1 Diabetes
por: Ize-Ludlow, Diego, et al.
Publicado: (2011)

The Peri-islet Basement Membrane, a Barrier to Infiltrating Leukocytes in Type 1 Diabetes in Mouse and Human
por: Korpos, Éva, et al.
Publicado: (2013)

A Novel Nonsense INS Mutation Causes Inefficient Preproinsulin Translocation Into the Endoplasmic Reticulum
por: Yang, Ying, et al.
Publicado: (2022)

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic β-Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes
por: Gaddy, Daniel F., et al.
Publicado: (2010)

Regulated and Reversible Induction of Adult Human β-Cell Replication
por: Takane, Karen K., et al.
Publicado: (2012)

Virgin β-Cells at the Neogenic Niche Proliferate Normally and Mature Slowly
por: Lee, Sharon, et al.
Publicado: (2021)

Bcl-2 and Bcl-x(L) Suppress Glucose Signaling in Pancreatic β-Cells
por: Luciani, Dan S., et al.
Publicado: (2013)

Connective Tissue Growth Factor Modulates Adult β-Cell Maturity and Proliferation to Promote β-Cell Regeneration in Mice
por: Riley, Kimberly G., et al.
Publicado: (2015)

GPR43 Potentiates β-Cell Function in Obesity
por: McNelis, Joanne C., et al.
Publicado: (2015)

Decreased Fetal Size Is Associated With β-Cell Hyperfunction in Early Life and Failure With Age
por: Chakravarthy, Manu V., et al.
Publicado: (2008)

Hepatocyte Growth Factor Enhances Engraftment and Function of Nonhuman Primate Islets
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2008)

Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion
por: Golson, Maria L., et al.
Publicado: (2015)

Lessons From the First Comprehensive Molecular Characterization of Cell Cycle Control in Rodent Insulinoma Cell Lines
por: Cozar-Castellano, Irene, et al.
Publicado: (2008)

Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and K(ATP) Channel Inhibition
por: Düfer, Martina, et al.
Publicado: (2012)

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6
por: Fiaschi-Taesch, Nathalie M., et al.
Publicado: (2010)

Soluble Factors Secreted by T Cells Promote β-Cell Proliferation
por: Dirice, Ercument, et al.
Publicado: (2014)

Parathyroid Hormone–Related Protein Enhances Human β-Cell Proliferation and Function With Associated Induction of Cyclin-Dependent Kinase 2 and Cyclin E Expression
por: Guthalu Kondegowda, Nagesha, et al.
Publicado: (2010)

Disruption of Hepatocyte Growth Factor/c-Met Signaling Enhances Pancreatic β-Cell Death and Accelerates the Onset of Diabetes
por: Mellado-Gil, Jose, et al.
Publicado: (2011)

The Effects of Glyburide on Apoptosis and Endoplasmic Reticulum Stress in INS-1 Cells in a Glucolipotoxic Condition
por: Kwon, Min Jeong, et al.
Publicado: (2011)

Changes of MODY signal pathway genes in the endoplasmic reticulum stress in INS-1-3 cells
por: Dong, Yanan, et al.
Publicado: (2018)

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells
por: Chen, Hainan, et al.
Publicado: (2015)

In Vivo Role of Focal Adhesion Kinase in Regulating Pancreatic β-Cell Mass and Function Through Insulin Signaling, Actin Dynamics, and Granule Trafficking
por: Cai, Erica P., et al.
Publicado: (2012)

Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
por: Rosengren, Anders H., et al.
Publicado: (2012)

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice
por: Lin, Haopeng, et al.
Publicado: (2021)

ChREBP Mediates Glucose-Stimulated Pancreatic β-Cell Proliferation
por: Metukuri, Mallikarjuna R., et al.
Publicado: (2012)

Radiomanganese PET Detects Changes in Functional β-Cell Mass in Mouse Models of Diabetes
por: Hernandez, Reinier, et al.
Publicado: (2017)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

Pathological β-Cell Endoplasmic Reticulum Stress in Type 2 Diabetes: Current Evidence
por: Shrestha, Neha, et al.
Publicado: (2021)

National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities
por: Ricordi, Camillo, et al.
Publicado: (2016)

Glucolipotoxicity Impairs Ceramide Flow from the Endoplasmic Reticulum to the Golgi Apparatus in INS-1 β-Cells
por: Gjoni, Enida, et al.
Publicado: (2014)

Endoplasmic reticulum stress induced by lipopolysaccharide is involved in the association between inflammation and autophagy in INS-1 cells
por: Liu, Han, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_b699lnib6bvj428ef0mgo8pv2o