Computational design of mixed chirality peptide macrocycles with internal symmetry

Cyclic symmetry is frequent in protein and peptide homo‐oligomers, but extremely rare within a single chain, as it is not compatible with free N‐ and C‐termini. Here we describe the computational design of mixed‐chirality peptide macrocycles with rigid structures that feature internal cyclic symmetr...

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Detalles Bibliográficos
Autores principales: Mulligan, Vikram Khipple, Kang, Christine S., Sawaya, Michael R., Rettie, Stephen, Li, Xinting, Antselovich, Inna, Craven, Timothy W., Watkins, Andrew M., Labonte, Jason W., DiMaio, Frank, Yeates, Todd O., Baker, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2020
Materias:
Full‐Length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679966/
https://www.ncbi.nlm.nih.gov/pubmed/33058266
http://dx.doi.org/10.1002/pro.3974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679966/
https://www.ncbi.nlm.nih.gov/pubmed/33058266
http://dx.doi.org/10.1002/pro.3974

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