Pre-depletion of TRBC1+ T cells promotes the therapeutic efficacy of anti-TRBC1 CAR-T for T-cell malignancies

Targeting T cell receptor β-chain constant region 1 (TRBC1) CAR-T could specifically kill TRBC1+ T-cell malignancies. However, over-expressed CARs on anti-TRBC1 CAR transduced TRBC1+ T cells (CAR-C1) bound to autologous TRBC1, masking TRBC1 from identification by other anti-TRBC1 CAR-T, and moreover...

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Detalles Bibliográficos
Autores principales: Zhang, Chaoting, Palashati, Heyilimu, Rong, Zhuona, Lin, Ningjing, Shen, Luyan, Liu, Ying, Li, Shance, Yu, Bentong, Yang, Wenjun, Lu, Zheming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679992/
https://www.ncbi.nlm.nih.gov/pubmed/33218364
http://dx.doi.org/10.1186/s12943-020-01282-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7679992/
https://www.ncbi.nlm.nih.gov/pubmed/33218364
http://dx.doi.org/10.1186/s12943-020-01282-7

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