Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer

BACKGROUND: This study aimed to systematically profile the alterations and sex- and age-related differences in the drug metabolizing enzymes (DMEs) in a KRAS-mutant mouse model of lung cancer (KRAS mice). METHODOLOGY: In this study, the LC-MS/MS approach and a probe substrate method were used to det...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiaoyan, Lu, Yiyan, Ou, Xiaojun, Zeng, Sijing, Wang, Ying, Qi, Xiaoxiao, Zhu, Lijun, Liu, Zhongqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2020
Materias:
Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680056/
https://www.ncbi.nlm.nih.gov/pubmed/33240601
http://dx.doi.org/10.7717/peerj.10182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680056/
https://www.ncbi.nlm.nih.gov/pubmed/33240601
http://dx.doi.org/10.7717/peerj.10182

Ejemplares similares