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Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer

BACKGROUND: This study aimed to systematically profile the alterations and sex- and age-related differences in the drug metabolizing enzymes (DMEs) in a KRAS-mutant mouse model of lung cancer (KRAS mice). METHODOLOGY: In this study, the LC-MS/MS approach and a probe substrate method were used to det...

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Detalles Bibliográficos
Autores principales:	Li, Xiaoyan, Lu, Yiyan, Ou, Xiaojun, Zeng, Sijing, Wang, Ying, Qi, Xiaoxiao, Zhu, Lijun, Liu, Zhongqiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2020
Materias:	Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680056/ https://www.ncbi.nlm.nih.gov/pubmed/33240601 http://dx.doi.org/10.7717/peerj.10182

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