Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes

McrBC complexes are motor-driven nucleases functioning in bacterial self-defense by cleaving foreign DNA. The GTP-specific AAA + protein McrB powers translocation along DNA and its hydrolysis activity is stimulated by its partner nuclease McrC. Here, we report cryo-EM structures of Thermococcus gamm...

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Detalles Bibliográficos
Autores principales: Niu, Yiming, Suzuki, Hiroshi, Hosford, Christopher J., Walz, Thomas, Chappie, Joshua S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680126/
https://www.ncbi.nlm.nih.gov/pubmed/33219217
http://dx.doi.org/10.1038/s41467-020-19735-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680126/
https://www.ncbi.nlm.nih.gov/pubmed/33219217
http://dx.doi.org/10.1038/s41467-020-19735-4

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