Nucleotide-binding sites can enhance N-acylation of nearby protein lysine residues

Acyl-CoAs are reactive metabolites that can non-enzymatically S-acylate and N-acylate protein cysteine and lysine residues, respectively. N-acylation is irreversible and enhanced if a nearby cysteine residue undergoes an initial reversible S-acylation, as proximity leads to rapid S → N-transfer of t...

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Detalles Bibliográficos
Autores principales: James, Andrew M., Smith, Anthony C., Ding, Shujing, Houghton, Jack W., Robinson, Alan J., Antrobus, Robin, Fearnley, Ian M., Murphy, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680127/
https://www.ncbi.nlm.nih.gov/pubmed/33219268
http://dx.doi.org/10.1038/s41598-020-77261-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680127/
https://www.ncbi.nlm.nih.gov/pubmed/33219268
http://dx.doi.org/10.1038/s41598-020-77261-1

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