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Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation
Somatic mutations in the RAS genes are frequent in human tumors, especially in pancreatic, colorectal, and non-small-cell lung cancers. Such mutations generally decrease the ability of Ras to hydrolyze GTP, maintaining the protein in a constitutively active GTP-bound form that drives uncontrolled ce...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680326/ https://www.ncbi.nlm.nih.gov/pubmed/32936431 http://dx.doi.org/10.1007/s10555-020-09918-2 |