Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation

To assess the effects of acylcarnitine accumulation on muscle insulin sensitivity, a model of muscle acylcarnitine accumulation was generated by deleting carnitine palmitoyltransferase 2 (CPT2) specifically from skeletal muscle (Cpt2(Sk−/−) mice). CPT2 is an irreplaceable enzyme for mitochondrial lo...

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Detalles Bibliográficos
Autores principales: Pereyra, Andrea S., Rajan, Arvind, Ferreira, Christina R., Ellis, Jessica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680579/
https://www.ncbi.nlm.nih.gov/pubmed/33176143
http://dx.doi.org/10.1016/j.celrep.2020.108374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680579/
https://www.ncbi.nlm.nih.gov/pubmed/33176143
http://dx.doi.org/10.1016/j.celrep.2020.108374

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