Multi-Set Testing Strategies Show Good Behavior When Applied to Very Large Sets of Rare Variants

Gene-based tests of association (e.g., variance components and burden tests) are now common practice for analyses attempting to elucidate the contribution of rare genetic variants on common disease. As sequencing datasets continue to grow in size, the number of variants within each set (e.g., gene)...

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Detalles Bibliográficos
Autores principales: Fore, Ruby, Boehme, Jaden, Li, Kevin, Westra, Jason, Tintle, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680887/
https://www.ncbi.nlm.nih.gov/pubmed/33240333
http://dx.doi.org/10.3389/fgene.2020.591606

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680887/
https://www.ncbi.nlm.nih.gov/pubmed/33240333
http://dx.doi.org/10.3389/fgene.2020.591606

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