Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation

In tryptophan biosynthesis, the reaction catalyzed by the enzyme indole-3-glycerol phosphate synthase (IGPS) starts with a condensation step in which the substrate's carboxylated phenyl group makes a nucleophilic attack to form the pyrrole ring of the indole, followed by a decarboxylation that...

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Detalles Bibliográficos
Autores principales: Söderholm, Annika, Newton, Matilda S., Patrick, Wayne M., Selmer, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Enzymology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681013/
https://www.ncbi.nlm.nih.gov/pubmed/32928960
http://dx.doi.org/10.1074/jbc.RA120.014936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681013/
https://www.ncbi.nlm.nih.gov/pubmed/32928960
http://dx.doi.org/10.1074/jbc.RA120.014936

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