Cargando…

Blood extracellular vesicles from healthy individuals regulate hematopoietic stem cells as humans age

Hematopoietic stem cells (HSCs) maintain balanced blood cell production in a process called hematopoiesis. As humans age, their HSCs acquire mutations that allow some HSCs to disproportionately contribute to normal blood production. This process, known as age‐related clonal hematopoiesis, predispose...

Descripción completa

Detalles Bibliográficos
Autores principales:	Grenier‐Pleau, Isabelle, Tyryshkin, Kathrin, Le, Tri Dung, Rudan, John, Bonneil, Eric, Thibault, Pierre, Zeng, Karen, Lässer, Cecilia, Mallinson, David, Lamprou, Dimitrios, Hui, Jialui, Postovit, Lynne‐Marie, Chan, Edmond Y. W., Abraham, Sheela A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Short Takes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681054/ https://www.ncbi.nlm.nih.gov/pubmed/33029858 http://dx.doi.org/10.1111/acel.13245

Ejemplares similares

The aged hematopoietic system promotes hippocampal‐dependent cognitive decline
por: Smith, Lucas K., et al.
Publicado: (2020)

In a randomized trial in prostate cancer patients, dietary protein restriction modifies markers of leptin and insulin signaling in plasma extracellular vesicles
por: Eitan, Erez, et al.
Publicado: (2017)

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence
por: Mohrin, Mary, et al.
Publicado: (2018)

Long‐term mid‐onset dietary restriction rejuvenates hematopoietic stem cells and improves regeneration capacity of total bone marrow from aged mice
por: Tao, Si, et al.
Publicado: (2020)

The SKN‐1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms
por: Tullet, Jennifer M.A., et al.
Publicado: (2017)

Paternal age and telomere length in twins: the germ stem cell selection paradigm
por: Hjelmborg, Jacob B, et al.
Publicado: (2015)

Mitochondrial turnover in liver is fast in vivo and is accelerated by dietary restriction: application of a simple dynamic model
por: Miwa, Satomi, et al.
Publicado: (2008)

The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons
por: Reeve, Amy K, et al.
Publicado: (2009)

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging
por: Hackl, Matthias, et al.
Publicado: (2010)

Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts
por: Nooteboom, Marco, et al.
Publicado: (2010)

The overexpression of major antioxidant enzymes does not extend the lifespan of mice
por: Pérez, Viviana I, et al.
Publicado: (2009)

Age-related variation in immunity in a wild mammal population
por: Nussey, Daniel H, et al.
Publicado: (2012)

Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs
por: Waters, David J, et al.
Publicado: (2009)

Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts
por: Saha, Bidisha, et al.
Publicado: (2014)

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity
por: Milman, Sofiya, et al.
Publicado: (2014)

IGF-I regulates the age-dependent signaling peptide humanin
por: Lee, Changhan, et al.
Publicado: (2014)

A genomics approach identifies senescence-specific gene expression regulation
por: Lackner, Daniel H, et al.
Publicado: (2014)

Deleted in Breast Cancer 1 regulates cellular senescence during obesity
por: Escande, Carlos, et al.
Publicado: (2014)

Shared signatures of social stress and aging in peripheral blood mononuclear cell gene expression profiles
por: Snyder-Mackler, Noah, et al.
Publicado: (2014)

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice
por: Mercken, Evi M, et al.
Publicado: (2014)

Vitamin A deficiency: what eye health workers can do
por: Adebisi, Babajide, et al.
Publicado: (2013)

Do altered energy metabolism or spontaneous locomotion ‘mediate’ decelerated senescence?
por: Arum, Oge, et al.
Publicado: (2015)

The rejuvenating effect of pregnancy on muscle regeneration
por: Falick Michaeli, Tal, et al.
Publicado: (2015)

Haploinsufficiency of myostatin protects against aging-related declines in muscle function and enhances the longevity of mice
por: Mendias, Christopher L, et al.
Publicado: (2015)

The life-extending effect of dietary restriction requires Foxo3 in mice
por: Shimokawa, Isao, et al.
Publicado: (2015)

Increased gene dosage of Ink4/Arf and p53 delays age-associated central nervous system functional decline
por: Carrasco-Garcia, Estefania, et al.
Publicado: (2015)

Age‐related changes in murine myometrial transcript profile are mediated by exposure to the female sex hormones
por: Chong, Hsu P., et al.
Publicado: (2015)

Intact endothelial autophagy is required to maintain vascular lipid homeostasis
por: Torisu, Kumiko, et al.
Publicado: (2015)

Central insulin‐like growth factor‐1 (IGF‐1) restores whole‐body insulin action in a model of age‐related insulin resistance and IGF‐1 decline
por: Huffman, Derek M., et al.
Publicado: (2015)

Infection susceptibility and immune senescence with advancing age replicated in accelerated aging Lmna (Dhe) mice
por: Xin, Lijun, et al.
Publicado: (2015)

Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response
por: Valapala, Mallika, et al.
Publicado: (2014)

Immunochip analysis identifies association of the RAD50/IL13 region with human longevity
por: Flachsbart, Friederike, et al.
Publicado: (2016)

Lack of evidence for GDF11 as a rejuvenator of aged skeletal muscle satellite cells
por: Hinken, Aaron C., et al.
Publicado: (2016)

CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
por: Spyridopoulos, Ioakim, et al.
Publicado: (2015)

Follicle-stimulating hormone promotes age-related endometrial atrophy through cross-talk with transforming growth factor beta signal transduction pathway
por: Zhang, Dan, et al.
Publicado: (2015)

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human
por: MacRae, Sheila L, et al.
Publicado: (2015)

Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress
por: Page, Melissa M, et al.
Publicado: (2014)

Endoplasmic reticulum stress activates telomerase
por: Zhou, Junzhi, et al.
Publicado: (2014)

Superoxide signaling in perivascular adipose tissue promotes age-related artery stiffness
por: Fleenor, Bradley S, et al.
Publicado: (2014)

Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress
por: Chew, Yee Lian, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7esobgt5r6o289jmdv88iheuoc