TDP-43 proteinopathy impairs mRNP granule mediated postsynaptic translation and mRNA metabolism

Background: Local protein synthesis and mRNA metabolism mediated by mRNP granules in the dendrites and the postsynaptic compartment is essential for synaptic remodeling and plasticity in neuronal cells. Dysregulation of these processes caused by TDP-43 proteinopathy leads to neurodegenerative diseas...

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Detalles Bibliográficos
Autores principales: Wong, Chia-En, Jin, Lee-Way, Chu, Yuan-Ping, Wei, Wei-Yen, Ho, Pei-Chuan, Tsai, Kuen-Jer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681104/
https://www.ncbi.nlm.nih.gov/pubmed/33391478
http://dx.doi.org/10.7150/thno.51004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681104/
https://www.ncbi.nlm.nih.gov/pubmed/33391478
http://dx.doi.org/10.7150/thno.51004

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