Cargando…

Downregulation of histone-lysine N-methyltransferase EZH2 inhibits cell viability and enhances chemosensitivity in lung cancer cells

Histone-lysine N-methyltransferase EZH2 (EZH2) is the principle component of the polycomb repressive complex 2 (PRC2)/embryonic ectoderm development protein-EZH2 complex, which promotes tumorigenesis by repressing transcription of tumor suppressor genes. EZH2 is considered a key marker in several ty...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Ziyang, Wu, Wei, Wei, Haiting, Zhang, Wei, Huang, Yan, Dong, Zhengwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681225/ https://www.ncbi.nlm.nih.gov/pubmed/33240432 http://dx.doi.org/10.3892/ol.2020.12287

Ejemplares similares

Lysine Ethylation by Histone Lysine Methyltransferases
por: Al Temimi, Abbas H. K., et al.
Publicado: (2019)

Chemical Probes of Histone Lysine Methyltransferases
por: Kaniskan, H. Ümit, et al.
Publicado: (2014)

Multiple regulatory aspects of histone methyltransferase EZH2 in Pb-induced neurotoxicity
por: Xue, Wei-Zhen, et al.
Publicado: (2017)

Autophagy deficiency downregulates O(6)methylguanine-DNA methyltransferase and increases chemosensitivity of liver cancer cells
por: Hou, Xiaojuan, et al.
Publicado: (2021)

Histone methyltransferase NSD2 regulates apoptosis and chemosensitivity in osteosarcoma
por: He, Chao, et al.
Publicado: (2019)

Lysine Possesses the Optimal Chain Length for Histone Lysine Methyltransferase Catalysis
por: Temimi, Abbas H. K. Al, et al.
Publicado: (2017)

Examining sterically demanding lysine analogs for histone lysine methyltransferase catalysis
por: Temimi, Abbas H. K. Al, et al.
Publicado: (2020)

The histone methyltransferase Ezh2 restrains macrophage inflammatory responses
por: Kitchen, Gareth B., et al.
Publicado: (2021)

Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma
por: Yan, Libin, et al.
Publicado: (2019)

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
por: Curry, Edward, et al.
Publicado: (2015)

Lysine methyltransferase SETD6 modifies histones on a glycine-lysine motif
por: Binda, Olivier
Publicado: (2019)

Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases
por: Al Temimi, Abbas H. K., et al.
Publicado: (2020)

Role of several histone lysine methyltransferases in tumor development
por: LI, JIFU, et al.
Publicado: (2016)

The role of histone lysine methyltransferase NSD3 in cancer
por: Han, Xu, et al.
Publicado: (2018)

Targets of histone H3 lysine 9 methyltransferases
por: Levinsky, Aidan J., et al.
Publicado: (2022)

The Roles of Histone Lysine Methyltransferases in Heart Development and Disease
por: Zhu, Jun-yi, et al.
Publicado: (2023)

Inhibition of histone methyltransferase EZH2 ameliorates early acute renal allograft rejection in rats
por: Li, Long, et al.
Publicado: (2016)

Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids
por: Mola, Silvia, et al.
Publicado: (2021)

Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells
por: Watanabe, Hideo, et al.
Publicado: (2008)

Modulation of the activity of histone lysine methyltransferases and demethylases by curcumin analog in leukaemia cells
por: Sawesi, Suhila, et al.
Publicado: (2022)

Aberrant Activity of Histone–Lysine N-Methyltransferase 2 (KMT2) Complexes in Oncogenesis
por: Poreba, Elzbieta, et al.
Publicado: (2020)

The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
por: Miele, Evelina, et al.
Publicado: (2017)

Histone‐lysine N‐methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc‐driven liver cancer
por: Thng, Dexter Kai Hao, et al.
Publicado: (2023)

Downregulation of Histone H3 Lysine 9 Methyltransferase G9a Induces Centrosome Disruption and Chromosome Instability in Cancer Cells
por: Kondo, Yutaka, et al.
Publicado: (2008)

Augmented Production of Platelets From Cord Blood With Euchromatic Histone Lysine Methyltransferase Inhibition
por: Liu, Yiying, et al.
Publicado: (2022)

Downregulation of histone methyltransferase SET8 inhibits progression of hepatocellular carcinoma
por: Wu, Jianhua, et al.
Publicado: (2020)

Genetic alterations of histone lysine methyltransferases and their significance in breast cancer
por: Liu, Lanxin, et al.
Publicado: (2014)

New epigenetic pathway for stemness maintenance mediated by the histone methyltransferase Ezh1
por: Hidalgo, Isabel, et al.
Publicado: (2013)

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
por: Zhou, Jie, et al.
Publicado: (2019)

Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases
por: Li, Tingting, et al.
Publicado: (2021)

S-Adenosyl-l-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells
por: Liu, Tsang-Pai, et al.
Publicado: (2015)

The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer
por: Li, Jiaping, et al.
Publicado: (2019)

The cytoplasmic fraction of the histone lysine methyltransferase Setdb1 is essential for embryonic stem cells
por: Rapone, Roberta, et al.
Publicado: (2023)

The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation
por: Kojima, Machiko, et al.
Publicado: (2019)

Retraction: Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease
por: Herrera-Merchan, A, et al.
Publicado: (2017)

The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection
por: Chen, Xiangyu, et al.
Publicado: (2019)

Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage
por: Caruso, Lisa B., et al.
Publicado: (2018)

Silencing of histone methyltransferase NSD3 reduces cell viability in osteosarcoma with induction of apoptosis
por: Liu, Zhiwei, et al.
Publicado: (2017)

The Target of the NSD Family of Histone Lysine Methyltransferases Depends on the Nature of the Substrate
por: Li, Yan, et al.
Publicado: (2009)

Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer
por: Zhang, Yangjun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_i0oq6tb5n709pk56c8c7le9dfc