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Large transient capacitive currents in wild-type lysosomal Cl(−)/H(+) antiporter ClC-7 and residual transport activity in the proton glutamate mutant E312A
ClC-7 is a lysosomal 2 Cl(−)/1 H(+) antiporter of the CLC protein family, which comprises Cl(−) channels and other Cl(−)/H(+) antiporters. Mutations in ClC-7 and its associated β subunit Ostm1 lead to osteopetrosis and lysosomal storage disease in humans and mice. Previous studies on other mammalian...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681918/ https://www.ncbi.nlm.nih.gov/pubmed/33211806 http://dx.doi.org/10.1085/jgp.202012583 |