Different arrhythmia-associated calmodulin mutations have distinct effects on cardiac SK channel regulation

Calmodulin (CaM) plays a critical role in intracellular signaling and regulation of Ca(2+)-dependent proteins and ion channels. Mutations in CaM cause life-threatening cardiac arrhythmias. Among the known CaM targets, small-conductance Ca(2+)-activated K(+) (SK) channels are unique, since they are g...

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Detalles Bibliográficos
Autores principales: Ledford, Hannah A., Park, Seojin, Muir, Duncan, Woltz, Ryan L., Ren, Lu, Nguyen, Phuong T., Sirish, Padmini, Wang, Wenying, Sihn, Choong-Ryoul, George, Alfred L., Knollmann, Björn C., Yamoah, Ebenezer N., Yarov-Yarovoy, Vladimir, Zhang, Xiao-Dong, Chiamvimonvat, Nipavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681919/
https://www.ncbi.nlm.nih.gov/pubmed/33211795
http://dx.doi.org/10.1085/jgp.202012667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7681919/
https://www.ncbi.nlm.nih.gov/pubmed/33211795
http://dx.doi.org/10.1085/jgp.202012667

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