Antibody-mediated activation of the FGFR1/Klothoβ complex corrects metabolic dysfunction and alters food preference in obese humans

Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and eating/drinking behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes expressed in adipocytes, pancreatic acinar cells, and the nervous system in mice. Chronic administration of recombinant FGF21 or engineered variants...

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Detalles Bibliográficos
Autores principales: Baruch, Amos, Wong, Chin, Chinn, Leslie W., Vaze, Anjali, Sonoda, Junichiro, Gelzleichter, Thomas, Chen, Shan, Lewin-Koh, Nicholas, Morrow, Linda, Dheerendra, Suresh, Boismenu, Richard, Gutierrez, Johnny, Wakshull, Eric, Wilson, Maria E., Arora, Puneet S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682391/
https://www.ncbi.nlm.nih.gov/pubmed/33139537
http://dx.doi.org/10.1073/pnas.2012073117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682391/
https://www.ncbi.nlm.nih.gov/pubmed/33139537
http://dx.doi.org/10.1073/pnas.2012073117

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