Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists

Although class A G protein−coupled receptors (GPCRs) can function as monomers, many of them form dimers and oligomers, but the mechanisms and functional relevance of such oligomerization is ill understood. Here, we investigate this problem for the CXC chemokine receptor 4 (CXCR4), a GPCR that regula...

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Detalles Bibliográficos
Autores principales: Işbilir, Ali, Möller, Jan, Arimont, Marta, Bobkov, Vladimir, Perpiñá-Viciano, Cristina, Hoffmann, Carsten, Inoue, Asuka, Heukers, Raimond, de Graaf, Chris, Smit, Martine J., Annibale, Paolo, Lohse, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682396/
https://www.ncbi.nlm.nih.gov/pubmed/33148803
http://dx.doi.org/10.1073/pnas.2013319117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682396/
https://www.ncbi.nlm.nih.gov/pubmed/33148803
http://dx.doi.org/10.1073/pnas.2013319117

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