Redox-mediated regulation of an evolutionarily conserved cross-β structure formed by the TDP43 low complexity domain

A methionine-rich low complexity (LC) domain is found within a C-terminal region of the TDP43 RNA-binding protein. Self-association of this domain leads to the formation of labile cross-β polymers and liquid-like droplets. Treatment with H(2)O(2) caused phenomena of methionine oxidation and droplet...

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Detalles Bibliográficos
Autores principales: Lin, Yi, Zhou, Xiaoming, Kato, Masato, Liu, Daifei, Ghaemmaghami, Sina, Tu, Benjamin P., McKnight, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682574/
https://www.ncbi.nlm.nih.gov/pubmed/33144500
http://dx.doi.org/10.1073/pnas.2012216117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682574/
https://www.ncbi.nlm.nih.gov/pubmed/33144500
http://dx.doi.org/10.1073/pnas.2012216117

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