The PAX-FOXO1s trigger fast trans-differentiation of chick embryonic neural cells into alveolar rhabdomyosarcoma with tissue invasive properties limited by S phase entry inhibition

The chromosome translocations generating PAX3-FOXO1 and PAX7-FOXO1 chimeric proteins are the primary hallmarks of the paediatric fusion-positive alveolar subtype of Rhabdomyosarcoma (FP-RMS). Despite the ability of these transcription factors to remodel chromatin landscapes and promote the expressio...

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Detalles Bibliográficos
Autores principales: Gonzalez Curto, Gloria, Der Vartanian, Audrey, Frarma, Youcef El-Mokhtar, Manceau, Line, Baldi, Lorenzo, Prisco, Selene, Elarouci, Nabila, Causeret, Frédéric, Korenkov, Daniil, Rigolet, Muriel, Aurade, Frédéric, De Reynies, Aurélien, Contremoulins, Vincent, Relaix, Frédéric, Faklaris, Orestis, Briscoe, James, Gilardi-Hebenstreit, Pascale, Ribes, Vanessa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682867/
https://www.ncbi.nlm.nih.gov/pubmed/33175861
http://dx.doi.org/10.1371/journal.pgen.1009164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682867/
https://www.ncbi.nlm.nih.gov/pubmed/33175861
http://dx.doi.org/10.1371/journal.pgen.1009164

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