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Using B cell receptor lineage structures to predict affinity

We are frequently faced with a large collection of antibodies, and want to select those with highest affinity for their cognate antigen. When developing a first-line therapeutic for a novel pathogen, for instance, we might look for such antibodies in patients that have recovered. There exist effecti...

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Detalles Bibliográficos
Autores principales: Ralph, Duncan K., Matsen, Frederick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682889/
https://www.ncbi.nlm.nih.gov/pubmed/33175831
http://dx.doi.org/10.1371/journal.pcbi.1008391