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Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters

Glutamate transporters are essential players in glutamatergic neurotransmission in the brain, where they maintain extracellular glutamate below cytotoxic levels and allow for rounds of transmission. The structural bases of their function are well established, particularly within a model archaeal hom...

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Detalles Bibliográficos
Autores principales: Wang, Xiaoyu, Boudker, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682989/
https://www.ncbi.nlm.nih.gov/pubmed/33155546
http://dx.doi.org/10.7554/eLife.58417