In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

Polycystic kidney disease (PKD) is a prevalent genetic disorder, characterized by the formation of kidney cysts that progressively lead to kidney failure. The currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative treatments. The sign...

Descripción completa

Detalles Bibliográficos
Autores principales: Booij, Tijmen H, Leonhard, Wouter N, Bange, Hester, Yan, Kuan, Fokkelman, Michiel, Plugge, Anna J, Veraar, Kimberley A M, Dauwerse, Johannes G, van Westen, Gerard J P, van de Water, Bob, Price, Leo S, Peters, Dorien J M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683017/
https://www.ncbi.nlm.nih.gov/pubmed/31065693
http://dx.doi.org/10.1093/jmcb/mjz029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683017/
https://www.ncbi.nlm.nih.gov/pubmed/31065693
http://dx.doi.org/10.1093/jmcb/mjz029

Ejemplares similares