CNS Transduction Benefits of AAV-PHP.eB over AAV9 Are Dependent on Administration Route and Mouse Strain

Adeno-associated viral (AAV) vectors are attractive tools for central nervous system (CNS) gene therapy because some vectors can cross the blood-brain barrier (BBB), allowing them to be used as minimally invasive treatments. A novel AAV vector recently evolved in vivo, AAV-PHP.eB, has been reported...

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Detalles Bibliográficos
Autores principales: Mathiesen, Sophie N., Lock, Jasmine L., Schoderboeck, Lucia, Abraham, Wickliffe C., Hughes, Stephanie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683292/
https://www.ncbi.nlm.nih.gov/pubmed/33294493
http://dx.doi.org/10.1016/j.omtm.2020.10.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683292/
https://www.ncbi.nlm.nih.gov/pubmed/33294493
http://dx.doi.org/10.1016/j.omtm.2020.10.011

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