Simultaneous Inhibition of Ornithine Decarboxylase 1 and Pyruvate Kinase M2 Exerts Synergistic Effects Against Hepatocellular Carcinoma Cells

PURPOSE: Previously, we showed that lactate promoted the proliferation and mobility of hepatocellular carcinoma (HCC) cells by increasing the expression of ornithine decarboxylase 1 (ODC1). In this study, we determined the relationship between ODC1 and pyruvate kinase M2 (PKM2, a key lactate metabol...

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Detalles Bibliográficos
Autores principales: Zeng, Zhirui, Lan, Jinzhi, Lei, Shan, Yang, Yushi, He, Zhiwei, Xue, Yan, Chen, Tengxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683510/
https://www.ncbi.nlm.nih.gov/pubmed/33244237
http://dx.doi.org/10.2147/OTT.S240535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683510/
https://www.ncbi.nlm.nih.gov/pubmed/33244237
http://dx.doi.org/10.2147/OTT.S240535

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