Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries

The diagnosis of somatic and germline TP53 mutations in human tumors or in individuals prone to various types of cancer has now reached the clinic. To increase the accuracy of the prediction of TP53 variant pathogenicity, we gathered functional data from three independent large-scale saturation muta...

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Detalles Bibliográficos
Autores principales: Carbonnier, Vincent, Leroy, Bernard, Rosenberg, Shai, Soussi, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683535/
https://www.ncbi.nlm.nih.gov/pubmed/33230179
http://dx.doi.org/10.1038/s41598-020-74892-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683535/
https://www.ncbi.nlm.nih.gov/pubmed/33230179
http://dx.doi.org/10.1038/s41598-020-74892-2

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