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Comprehensive assessment of TP53 loss of function using multiple combinatorial mutagenesis libraries
The diagnosis of somatic and germline TP53 mutations in human tumors or in individuals prone to various types of cancer has now reached the clinic. To increase the accuracy of the prediction of TP53 variant pathogenicity, we gathered functional data from three independent large-scale saturation muta...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683535/ https://www.ncbi.nlm.nih.gov/pubmed/33230179 http://dx.doi.org/10.1038/s41598-020-74892-2 |