Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

TRPC1/4/5 channels are non-specific cation channels implicated in a wide variety of diseases, and TRPC1/4/5 inhibitors have recently entered clinical trials. However, fundamental and translational studies require a better understanding of TRPC1/4/5 channel regulation by endogenous and exogenous fact...

Descripción completa

Detalles Bibliográficos
Autores principales: Wright, David J., Simmons, Katie J., Johnson, Rachel M., Beech, David J., Muench, Stephen P., Bon, Robin S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683545/
https://www.ncbi.nlm.nih.gov/pubmed/33230284
http://dx.doi.org/10.1038/s42003-020-01437-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683545/
https://www.ncbi.nlm.nih.gov/pubmed/33230284
http://dx.doi.org/10.1038/s42003-020-01437-8

Ejemplares similares