TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer’s disease

TDP-43 inclusions are found in many Alzheimer’s disease (AD) patients presenting faster disease progression and greater brain atrophy. Previously, we showed full-length TDP-43 forms spherical oligomers and perturbs amyloid-β (Aβ) fibrillization. To elucidate the role of TDP-43 in AD, here, we examin...

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Detalles Bibliográficos
Autores principales: Shih, Yao-Hsiang, Tu, Ling-Hsien, Chang, Ting-Yu, Ganesan, Kiruthika, Chang, Wei-Wei, Chang, Pao-Sheng, Fang, Yu-Sheng, Lin, Yeh-Tung, Jin, Lee-Way, Chen, Yun-Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683652/
https://www.ncbi.nlm.nih.gov/pubmed/33230138
http://dx.doi.org/10.1038/s41467-020-19786-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683652/
https://www.ncbi.nlm.nih.gov/pubmed/33230138
http://dx.doi.org/10.1038/s41467-020-19786-7

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