Altered conformational sampling along an evolutionary trajectory changes the catalytic activity of an enzyme

Several enzymes are known to have evolved from non-catalytic proteins such as solute-binding proteins (SBPs). Although attention has been focused on how a binding site can evolve to become catalytic, an equally important question is: how do the structural dynamics of a binding protein change as it b...

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Detalles Bibliográficos
Autores principales: Kaczmarski, Joe A., Mahawaththa, Mithun C., Feintuch, Akiva, Clifton, Ben E., Adams, Luke A., Goldfarb, Daniella, Otting, Gottfried, Jackson, Colin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683729/
https://www.ncbi.nlm.nih.gov/pubmed/33230119
http://dx.doi.org/10.1038/s41467-020-19695-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7683729/
https://www.ncbi.nlm.nih.gov/pubmed/33230119
http://dx.doi.org/10.1038/s41467-020-19695-9

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