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Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway
Autophagy is a highly conserved degradation process for long-lived intracellular proteins and organelles mediated by lysosomes. Deficits in the autophagy-lysosome pathway (ALP) have been linked to a variety of human diseases, including neurodegenerative diseases, lysosomal storage disorders, and can...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684757/ https://www.ncbi.nlm.nih.gov/pubmed/33292395 http://dx.doi.org/10.1186/s13020-020-00402-1 |
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author | Xu, Jie Zhang, Xiao-Qi Zhang, Zaijun |
author_facet | Xu, Jie Zhang, Xiao-Qi Zhang, Zaijun |
author_sort | Xu, Jie |
collection | PubMed |
description | Autophagy is a highly conserved degradation process for long-lived intracellular proteins and organelles mediated by lysosomes. Deficits in the autophagy-lysosome pathway (ALP) have been linked to a variety of human diseases, including neurodegenerative diseases, lysosomal storage disorders, and cancers. Transcription factor EB (TFEB) has been identified as a major regulator of autophagy and lysosomal biogenesis. Increasing evidence has demonstrated that TFEB activation can promote the clearance of toxic protein aggregates and regulate cellular metabolism. Traditional Chinese medicine (TCM)-derived natural products as important sources for drug discovery have been widely used for the treatment of various diseases associated with ALP dysfunction. Herein, we review (1) the regulation of TFEB and ALP; (2) TFEB and ALP dysregulation in human diseases; (3) TFEB activators from natural products and their potential uses. |
format | Online Article Text |
id | pubmed-7684757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-76847572020-11-24 Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway Xu, Jie Zhang, Xiao-Qi Zhang, Zaijun Chin Med Review Autophagy is a highly conserved degradation process for long-lived intracellular proteins and organelles mediated by lysosomes. Deficits in the autophagy-lysosome pathway (ALP) have been linked to a variety of human diseases, including neurodegenerative diseases, lysosomal storage disorders, and cancers. Transcription factor EB (TFEB) has been identified as a major regulator of autophagy and lysosomal biogenesis. Increasing evidence has demonstrated that TFEB activation can promote the clearance of toxic protein aggregates and regulate cellular metabolism. Traditional Chinese medicine (TCM)-derived natural products as important sources for drug discovery have been widely used for the treatment of various diseases associated with ALP dysfunction. Herein, we review (1) the regulation of TFEB and ALP; (2) TFEB and ALP dysregulation in human diseases; (3) TFEB activators from natural products and their potential uses. BioMed Central 2020-11-23 /pmc/articles/PMC7684757/ /pubmed/33292395 http://dx.doi.org/10.1186/s13020-020-00402-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Xu, Jie Zhang, Xiao-Qi Zhang, Zaijun Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway |
title | Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway |
title_full | Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway |
title_fullStr | Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway |
title_full_unstemmed | Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway |
title_short | Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway |
title_sort | transcription factor eb agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684757/ https://www.ncbi.nlm.nih.gov/pubmed/33292395 http://dx.doi.org/10.1186/s13020-020-00402-1 |
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