Discovery of Drug-Like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3

Small molecules that bind the SARS-CoV-2 nonstructural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to the ability of coronaviruses to evade cellular detection. A high-throughput assay...

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Detalles Bibliográficos
Autores principales: Virdi, Rajdeep S., Bavisotto, Robert V., Hopper, Nicholas C., Vuksanovic, Nemanja, Melkonian, Trevor R., Silvaggi, Nicholas R., Frick, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Laboratory Automation and Screening. Published by Elsevier Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684785/
https://www.ncbi.nlm.nih.gov/pubmed/32981460
http://dx.doi.org/10.1177/2472555220960428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684785/
https://www.ncbi.nlm.nih.gov/pubmed/32981460
http://dx.doi.org/10.1177/2472555220960428

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