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Identification of contributing genes of Huntington’s disease by machine learning

BACKGROUND: Huntington’s disease (HD) is an inherited disorder caused by the polyglutamine (poly-Q) mutations of the HTT gene results in neurodegeneration characterized by chorea, loss of coordination, cognitive decline. However, HD pathogenesis is still elusive. Despite the availability of a wide r...

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Detalles Bibliográficos
Autores principales: Cheng, Jack, Liu, Hsin-Ping, Lin, Wei-Yong, Tsai, Fuu-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7684976/
https://www.ncbi.nlm.nih.gov/pubmed/33228685
http://dx.doi.org/10.1186/s12920-020-00822-w