Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response

Mitochondrial–nuclear communication, known as retrograde signaling, is important for regulating nuclear gene expression in response to mitochondrial dysfunction. Previously, we have found that p32/C1qbp-deficient mice, which have a mitochondrial translation defect, show endoplasmic reticulum (ER) st...

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Detalles Bibliográficos
Autores principales: Sasaki, Katsuhiko, Uchiumi, Takeshi, Toshima, Takahiro, Yagi, Mikako, Do, Yura, Hirai, Haruka, Igami, Ko, Gotoh, Kazuhito, Kang, Dongchon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2020
Materias:
Molecular Bases of Health & Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685009/
https://www.ncbi.nlm.nih.gov/pubmed/33165592
http://dx.doi.org/10.1042/BSR20201289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685009/
https://www.ncbi.nlm.nih.gov/pubmed/33165592
http://dx.doi.org/10.1042/BSR20201289

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