Cargando…

Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response

Mitochondrial–nuclear communication, known as retrograde signaling, is important for regulating nuclear gene expression in response to mitochondrial dysfunction. Previously, we have found that p32/C1qbp-deficient mice, which have a mitochondrial translation defect, show endoplasmic reticulum (ER) st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sasaki, Katsuhiko, Uchiumi, Takeshi, Toshima, Takahiro, Yagi, Mikako, Do, Yura, Hirai, Haruka, Igami, Ko, Gotoh, Kazuhito, Kang, Dongchon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Molecular Bases of Health & Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685009/ https://www.ncbi.nlm.nih.gov/pubmed/33165592 http://dx.doi.org/10.1042/BSR20201289

Ejemplares similares

Mitochondrial translation deficiency impairs NAD(+)‐mediated lysosomal acidification
por: Yagi, Mikako, et al.
Publicado: (2021)

Mitochondrial and Nuclear Genomic Responses to Loss of LRPPRC Expression
por: Gohil, Vishal M., et al.
Publicado: (2010)

p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock
por: Sasaki, Katsuhiko, et al.
Publicado: (2017)

Mitochondrial dysfunction-induced high hCG associated with development of fetal growth restriction and pre-eclampsia with fetal growth restriction
por: Kiyokoba, Ryo, et al.
Publicado: (2022)

Improving lysosomal ferroptosis with NMN administration protects against heart failure
por: Yagi, Mikako, et al.
Publicado: (2023)

p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability
por: Yagi, Mikako, et al.
Publicado: (2012)

Mitochondrial haplotype mutation alleviates respiratory defect of MELAS by restoring taurine modification in tRNA with 3243A > G mutation
por: Ueda, Saori, et al.
Publicado: (2023)

Chronic Ethanol Consumption Inhibits Glucokinase Transcriptional Activity by Atf3 and Triggers Metabolic Syndrome in Vivo
por: Kim, Ji Yeon, et al.
Publicado: (2014)

ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation
por: Uchiumi, Takeshi, et al.
Publicado: (2010)

ERAD deficiency promotes mitochondrial dysfunction and transcriptional rewiring in human hepatic cells
por: Liu, Qingqing, et al.
Publicado: (2021)

Understanding the Functional Interplay between Mammalian Mitochondrial Hsp70 Chaperone Machine Components
por: Goswami, Arvind Vittal, et al.
Publicado: (2010)

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
por: Ebert, Scott M., et al.
Publicado: (2015)

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ
por: Ebert, Scott M., et al.
Publicado: (2020)

Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects against Neurodegeneration in Experimental Multiple Sclerosis
por: Warne, Justin, et al.
Publicado: (2016)

Mitochondrial unfolded protein response gene CLPP changes mitochondrial dynamics and affects mitochondrial function
por: Wu, GuiJun, et al.
Publicado: (2019)

Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
por: Miki, Kenji, et al.
Publicado: (2022)

Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase
por: Birsa, Nicol, et al.
Publicado: (2014)

Correction: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation
por: Miki, Kenji, et al.
Publicado: (2022)

Expression of Mitochondrial Non-coding RNAs (ncRNAs) Is Modulated by High Risk Human Papillomavirus (HPV) Oncogenes
por: Villota, Claudio, et al.
Publicado: (2012)

Down-regulation of the Antisense Mitochondrial Non-coding RNAs (ncRNAs) Is a Unique Vulnerability of Cancer Cells and a Potential Target for Cancer Therapy
por: Vidaurre, Soledad, et al.
Publicado: (2014)

The Legs at odd angles (Loa) Mutation in Cytoplasmic Dynein Ameliorates Mitochondrial Function in SOD1(G93A) Mouse Model for Motor Neuron Disease
por: El-Kadi, Ali Morsi, et al.
Publicado: (2010)

Mitochondrial Protein Synthesis Is Essential for Terminal Differentiation of CD45(–) TER119(–)Erythroid and Lymphoid Progenitors
por: Gotoh, Kazuhito, et al.
Publicado: (2020)

Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration
por: Yagi, Mikako, et al.
Publicado: (2017)

Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions
por: Lynch, David R., et al.
Publicado: (2021)

High confidence ATFS-1 target genes for quantifying activation of the mitochondrial unfolded protein response
por: Soo, Sonja K, et al.
Publicado: (2021)

TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation
por: Fujii, Masakazu, et al.
Publicado: (2022)

Talin1 Has Unique Expression versus Talin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload
por: Manso, Ana Maria, et al.
Publicado: (2013)

An aberrantly sustained emergency granulopoiesis response accelerates postchemotherapy relapse in MLL1-rearranged acute myeloid leukemia in mice
por: Wang, Hao, et al.
Publicado: (2020)

ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response
por: Liu, Yifei, et al.
Publicado: (2023)

The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression
por: Amamoto, Rie, et al.
Publicado: (2016)

Dihydro-orotate dehydrogenase is physically associated with the respiratory complex and its loss leads to mitochondrial dysfunction
por: Fang, JingXian, et al.
Publicado: (2013)

Inhibition of p38 Mitogen-activated Protein Kinase Impairs Influenza Virus-induced Primary and Secondary Host Gene Responses and Protects Mice from Lethal H5N1 Infection
por: Börgeling, Yvonne, et al.
Publicado: (2014)

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways
por: Wu, Ziyun, et al.
Publicado: (2018)

Structure, Folding Dynamics, and Amyloidogenesis of D76N β(2)-Microglobulin: ROLES OF SHEAR FLOW, HYDROPHOBIC SURFACES, AND α-CRYSTALLIN
por: Mangione, P. Patrizia, et al.
Publicado: (2013)

Metformin directly binds the alarmin HMGB1 and inhibits its proinflammatory activity
por: Horiuchi, Takahiro, et al.
Publicado: (2017)

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA
por: Matsuda, Shigeru, et al.
Publicado: (2018)

Induction of glioblastoma cell ferroptosis using combined treatment with chloramphenicol and 2-deoxy-d-glucose
por: Miki, Kenji, et al.
Publicado: (2023)

Mitochondrial Reactive Oxygen Species Are Essential for the Development of Psoriatic Inflammation
por: Mizuguchi, Soichi, et al.
Publicado: (2021)

Decreased Mitochondrial Membrane Potential Activates the Mitochondrial Unfolded Protein Response
por: Berry, Brandon J., et al.
Publicado: (2021)

Folding Mitochondrial-Mediated Cytosolic Proteostasis Into the Mitochondrial Unfolded Protein Response
por: Jenkins, Edmund Charles, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vbdbgkenetr4h38770p1luf7n8