Dedicated transcriptomics combined with power analysis lead to functional understanding of genes with weak phenotypic changes in knockout lines

Systematic knockout studies in mice have shown that a large fraction of the gene replacements show no lethal or other overt phenotypes. This has led to the development of more refined analysis schemes, including physiological, behavioral, developmental and cytological tests. However, transcriptomic...

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Detalles Bibliográficos
Autores principales: Xie, Chen, Bekpen, Cemalettin, Künzel, Sven, Keshavarz, Maryam, Krebs-Wheaton, Rebecca, Skrabar, Neva, Ullrich, Kristian K., Zhang, Wenyu, Tautz, Diethard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685438/
https://www.ncbi.nlm.nih.gov/pubmed/33180766
http://dx.doi.org/10.1371/journal.pcbi.1008354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685438/
https://www.ncbi.nlm.nih.gov/pubmed/33180766
http://dx.doi.org/10.1371/journal.pcbi.1008354

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