Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation

Antigen cross presentation, whereby exogenous antigens are presented by MHC class I molecules to CD8+ T cells, is essential for generating adaptive immunity to pathogens and tumor cells. Following endocytosis, it is widely understood that protein antigens must be transferred from endosomes to the cy...

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Detalles Bibliográficos
Autores principales: Nalle, Sam C., Barreira da Silva, Rosa, Zhang, Hua, Decker, Markus, Chalouni, Cecile, Xu, Min, Posthuma, George, de Mazière, Ann, Klumperman, Judith, Baz Morelli, Adriana, Fleire, Sebastian J., Verkman, Alan S., Trombetta, E. Sergio, Albert, Matthew L., Mellman, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685505/
https://www.ncbi.nlm.nih.gov/pubmed/33232321
http://dx.doi.org/10.1371/journal.pone.0238484

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