The COX-2-derived PGE(2) autocrine contributes to bradykinin-induced matrix metalloproteinase-9 expression and astrocytic migration via STAT3 signaling

BACKGROUND: The matrix metalloproteinase-9 (MMP-9) is up-regulated by several proinflammatory mediators in the central nervous system (CNS) diseases. Increasing reports show that MMP-9 expression is an inflammatory biomarker of several CNS disorders, including the CNS inflammation and neurodegenerat...

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Detalles Bibliográficos
Autores principales: Lee, Tsong-Hai, Liu, Pei-Shan, Tsai, Ming-Ming, Chen, Jiun-Liang, Wang, Su-Jane, Hsieh, Hsi-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685582/
https://www.ncbi.nlm.nih.gov/pubmed/33228717
http://dx.doi.org/10.1186/s12964-020-00680-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685582/
https://www.ncbi.nlm.nih.gov/pubmed/33228717
http://dx.doi.org/10.1186/s12964-020-00680-0

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