Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished. We expressed different glycoforms of the Spike-protein and ACE2 in CRISPR-Cas9 glyco...

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Detalles Bibliográficos
Autores principales: Yang, Qi, Hughes, Thomas A, Kelkar, Anju, Yu, Xinheng, Cheng, Kai, Park, Sheldon, Huang, Wei-Chiao, Lovell, Jonathan F, Neelamegham, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685702/
https://www.ncbi.nlm.nih.gov/pubmed/33103998
http://dx.doi.org/10.7554/eLife.61552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685702/
https://www.ncbi.nlm.nih.gov/pubmed/33103998
http://dx.doi.org/10.7554/eLife.61552

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