Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross

Sequence variation in regulatory DNA alters gene expression and shapes genetically complex traits. However, the identification of individual, causal regulatory variants is challenging. Here, we used a massively parallel reporter assay to measure the cis-regulatory consequences of 5832 natural DNA va...

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Detalles Bibliográficos
Autores principales: Renganaath, Kaushik, Chong, Rockie, Day, Laura, Kosuri, Sriram, Kruglyak, Leonid, Albert, Frank W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685706/
https://www.ncbi.nlm.nih.gov/pubmed/33179598
http://dx.doi.org/10.7554/eLife.62669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685706/
https://www.ncbi.nlm.nih.gov/pubmed/33179598
http://dx.doi.org/10.7554/eLife.62669

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