High neural activity accelerates the decline of cognitive plasticity with age in Caenorhabditis elegans

The ability to learn progressively declines with age. Neural hyperactivity has been implicated in impairing cognitive plasticity with age, but the molecular mechanisms remain elusive. Here, we show that chronic excitation of the Caenorhabditis elegans O(2)-sensing neurons during ageing causes a rapi...

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Detalles Bibliográficos
Autores principales: Li, Qiaochu, Marcu, Daniel-Cosmin, Palazzo, Ottavia, Turner, Frances, King, Declan, Spires-Jones, Tara L, Stefan, Melanie I, Busch, Karl Emanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685709/
https://www.ncbi.nlm.nih.gov/pubmed/33228848
http://dx.doi.org/10.7554/eLife.59711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685709/
https://www.ncbi.nlm.nih.gov/pubmed/33228848
http://dx.doi.org/10.7554/eLife.59711

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