Matrix Metalloproteinase 14 Mediates APP Proteolysis and Lysosomal Alterations Induced by Oxidative Stress in Human Neuronal Cells

The alteration of amyloid precursor protein (APP) proteolysis is a hallmark of Alzheimer's disease (AD). Recent studies have described noncanonical pathways of APP processing that seem partly executed by lysosomal enzymes. Our laboratory's in vitro human SK-N-MC model has shown that oxidat...

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Detalles Bibliográficos
Autores principales: Llorente, Patricia, Martins, Soraia, Sastre, Isabel, Aldudo, Jesús, Recuero, María, Adjaye, James, Bullido, Maria J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685830/
https://www.ncbi.nlm.nih.gov/pubmed/33282112
http://dx.doi.org/10.1155/2020/5917187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7685830/
https://www.ncbi.nlm.nih.gov/pubmed/33282112
http://dx.doi.org/10.1155/2020/5917187

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